Ruthenium-Catalyzed Peri- and Ortho-Alkynylation with Bromoalkynes via Insertion and Elimination

نویسندگان

  • Eric Tan
  • Andrey I Konovalov
  • Gabriela A Fernández
  • Ruth Dorel
  • Antonio M Echavarren
چکیده

The alkynylation of naphthols takes place with total regiocontrol at the peri position of the hydroxyl group in the presence of [RuCl2(p-cymene)]2 as the catalyst. This reaction features high functional group tolerance. The related ortho-alkynylation of benzoic acids proceeds under similar conditions and also shows wide functional group tolerance. Both reactions proceed through metalation, insertion of the alkyne, and bromide elimination.

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عنوان ژورنال:

دوره 19  شماره 

صفحات  -

تاریخ انتشار 2017